Intervention
Quercetin
Last updated 2026-05-17· 1 min read
Reviewed by the Ultimate Longevity Bible editorial team. Educational reference — not medical advice. See disclaimer.
What it is
Quercetin is a flavonol abundant in onions, apples, capers, and many berries. As a supplement it’s commonly paired with dasatinib in senolytic protocols (D+Q), targeting BCL-xL and PI3K survival pathways in senescent cells.
Why it’s of interest
In senolytic combinations, quercetin clears senescent cells in adipose and other tissues in mice, improving multiple healthspan endpoints. As a solo over-the-counter supplement, its bioavailability is poor and the human longevity evidence is thin.
Other uses
- Marketed as an immune-support supplement (limited RCT support).
- Used as a zinc ionophore in some COVID-era off-label protocols (no endorsement implied).
- Cardiometabolic effects (modest reductions in blood pressure in some meta-analyses).
Safety
Generally well-tolerated at typical supplement doses (500–1000 mg/day). Concerns at high doses include nephrotoxicity (case reports) and drug-interaction potential via CYP3A4 inhibition.
- Apigenin — Intervention.
- Creatine Monohydrate — Intervention.
- NAD+ Precursors (NR & NMN) — Intervention.
- Spermidine — Intervention.
- Taurine — Intervention.
Related entries
References
- Zhu, Y. et al. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14, 644–658 (2015).