Researcher
Steve Horvath
Last updated 2026-05-17· 1 min read
Reviewed by the Ultimate Longevity Bible editorial team. Educational reference — not medical advice. See disclaimer.
Background
Steve Horvath trained in mathematics and biostatistics. He spent his academic career at UCLA before joining Altos Labs as a Principal Investigator. His work bridges biostatistics and biology of aging.
Key contributions
- 2013 Horvath clock — 353-CpG multi-tissue DNA-methylation biological-age estimator that works across nearly all human tissues and even some cell types. Founded the field of epigenetic clocks.
- Pan-mammalian clocks — methylation-age estimators that work across species, supporting the idea that aging has a conserved epigenetic component.
- Extensive collaborative work applying epigenetic clocks to interventions, disease states, and rejuvenation experiments.
Influence
Most longevity-intervention trials today measure epigenetic age as a near-term surrogate endpoint, exclusively because of Horvath’s clocks and their successors (PhenoAge, GrimAge, DunedinPACE).
Now
Joined Altos Labs in 2022 to apply pan-mammalian clocks to in-vivo rejuvenation work.
- Epigenetic Alterations — Hallmark.
- Morgan Levine — Researcher.
- Frailty Index — Biomarker.
- Telomere Length — Biomarker.
- GrimAge vs DunedinPACE — Comparison.
Related entries
References
- Horvath, S. DNA methylation age of human tissues and cell types. Genome Biol. 14, R115 (2013).