Steve Horvath

Background

Steve Horvath trained in mathematics and biostatistics. He spent his academic career at UCLA before joining Altos Labs as a Principal Investigator. His work bridges biostatistics and biology of aging.

Key contributions

• 2013 Horvath clock — 353-CpG multi-tissue DNA-methylation biological-age estimator that works across nearly all human tissues and even some cell types. Founded the field of epigenetic clocks.
• Pan-mammalian clocks — methylation-age estimators that work across species, supporting the idea that aging has a conserved epigenetic component.
• Extensive collaborative work applying epigenetic clocks to interventions, disease states, and rejuvenation experiments.

Influence

Most longevity-intervention trials today measure epigenetic age as a near-term surrogate endpoint, exclusively because of Horvath’s clocks and their successors (PhenoAge, GrimAge, DunedinPACE).

Now

Joined Altos Labs in 2022 to apply pan-mammalian clocks to in-vivo rejuvenation work.

Related entries

Epigenetic clocks, PhenoAge, Altos Labs.