Biomarker
Grip Strength
Last updated Sun May 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
What it is
Maximum isometric grip force measured by a handheld dynamometer (Jamar or equivalent). Standard protocol: seated, elbow at 90°, three trials per hand, record the best.
Why it matters
In the PURE study (~140,000 adults across 17 countries), each 5 kg reduction in grip strength corresponded to a 16% increase in all-cause mortality and a 17% increase in cardiovascular death. The association held across regions, ages, and adjusting for traditional risk factors.
Reference ranges (rough)
| Age | Men (kg) | Women (kg) |
|---|---|---|
| 20–40 | 45–55 | 28–35 |
| 40–60 | 40–50 | 26–33 |
| 60–80 | 28–42 | 18–28 |
| 80+ | 20–30 | 12–20 |
Below ~26 kg (men) or ~16 kg (women) is a sarcopenia/frailty threshold in many criteria.
Why it’s a powerful integrator
Grip strength reflects nutrition, motor-unit health, nervous-system integrity, and overall muscular conditioning. It’s a low-cost proxy for “general resilience” that ages predictively.
What improves it
Resistance training, particularly grip-loading exercises (deadlifts, farmer’s carries, hangs). Improvements are possible even in very elderly adults.
Related entries
References
- Leong, D. P. et al. Prognostic value of grip strength: findings from the PURE study. Lancet 386, 266–273 (2015).