Biomarker
DEXA Scan (Body Composition + Bone Density)
Last updated Sun May 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
What it is
A low-radiation X-ray (~0.001 mSv) that uses two energy levels to discriminate between fat, lean (muscle + organ + water), and bone. A typical DEXA scan reports:
- Total and regional lean mass (arms, legs, trunk).
- Total and regional fat mass.
- Visceral adipose tissue (VAT) — an estimate, not direct measurement.
- Bone mineral density (BMD) at hip, spine, and total body.
- T-score — standard deviations from young-adult mean BMD.
Why it matters
- Lean mass / appendicular lean mass index (ALMI) — sarcopenia diagnosis and tracking.
- Visceral fat — the metabolically harmful fat depot; weakly related to BMI.
- Bone density — osteoporosis screening and treatment monitoring.
T-score interpretation
- > −1.0: normal.
- −1.0 to −2.5: osteopenia.
- < −2.5: osteoporosis.
Frequency
For body composition and longevity tracking, annual scans are typical. For osteoporosis monitoring, every 1–2 years.
Limitations
- Hydration status modestly affects lean-mass measurement.
- VAT estimation is less accurate than CT/MRI but adequate for tracking.
- Cannot distinguish muscle from non-fat lean (water, organ tissue).
Related entries
References
- Shepherd, J. A. et al. Body composition by DXA. Bone 104, 101–105 (2017).